It depends where you set it up indoors. We did a mobile radio connected to a Tram 1185 on a pizza pan in my son’s room and it works just fine, but we had to move it around a bit to avoid interference with a smoke detector in the hallway.
We also connected a homemade slim jim antenna made of ladder line to a UV-5R and it worked depending on where we placed the antenna. If it was hung in certain parts of the room it picked up very little, but in very specific locations it was fine.
Lights, plumbing, electrical wiring, windows, walls, computers, general layout of the interior, multiple floors, roofing and other factors combine to make it a wild card. It really depends where your house is located, what is inside and around it and where you place the antenna within a room.